GENERX AND SIGNATURE SUPPLEMENTS

ABOUT SIGNATURE SUPPLEMENTS

  We are Canada’s leading custom compounding company and are truly PROFESSIONAL ONLY.
  Our products are exclusively available to qualified healthcare practitioners. 
  We are 100% Canadian owned and operated with 27+ years in the business.
  We offer customization and convenience to craft powerful, patient-specific formulas that set your practice apart.
  We offer Individual Custom Formulas for one patient or the ability to create your own Practitioner-Designed Stock Products that will best suit your clinic and patients.
  As a compounder, products are made by hand in small batches at the time of ordering.
  We have 450+ quality premium raw materials available.

GENERX PRODUCTS

Autophagy Activator

Autophagy is the body’s natural self-preservation mechanism for removing damaged or dysfunctional debris within cells and recycling them to regenerate new, healthier cells. Low autophagy is associated with a variety of diseases such as cancer, type-2 diabetes, dementia and cardiomyopathy.

This important product can be used as a fasting mimetic during FMD cycles or on a daily basis to promote stronger autophagy.

Dopamine Booster

This product combines the essential ingredients Mucuna Pruriens, L-Tyrosine and Bacopa Monniera, required to increase the production of dopamine. As stress can easily convert dopamine into adrenaline, Lactium is added to reduce activity in the HPA axis, reduce the stress response and prevent this conversion. Lactium also ensures that dopamine remains bound in the prefrontal cortex where it is needed for focus, concentration and mood control.

This unique formula is free of methylators and therefore prevents hypermethylation of several pathways until genes are reset. And, unlike many other formulations, Dopamine Booster does not contain Rhodiola, which can actually increase adrenaline in certain gene codings. This product may be combined with natural or pharmaceutical NDRIs to help support low mood, addictive behaviour, ADD and ADHD.

Dopamine Delivery

A formula designed to inhibit the reuptake of dopamine and increase its transportation to receptors. Ashwagandha and St. John’s Wort function like NDRIs (norepinephrine-dopamine reuptake inhibitors), increasing the delivery of dopamine to its target receptor without increasing the production of dopamine itself or its conversion into adrenaline. It has some mild SSRI (selective serotonin reuptake inhibitor) properties, boosting serotonin activity without increasing production, thereby avoiding the risk of serotonin syndrome.

This product may be combined with pharmaceutical NDRIs to support low mood, addictive behaviour, ADD and ADHD.

GABA Reset

A formula containing Passion Flower and L-Theanine, designed to balance the ratio of glutamate, the most abundant excitatory neurotransmitter, and GABA, the calming inhibitory neurotransmitter, thereby reducing excessive CNS excitation.

Glutathione Complex

A synergistic combination of S-Acetyl-Glutathione and NAC. The acetyl group attached to S-acetyl- glutathione (SAG), protects it from degradation as it passes through the GI tract, resulting in higher stability than most forms of glutathione. It has a faster, more efficient transportation through cellular membranes, yielding a rise in serum glutathione close to 37%, more than double that of other forms of glutathione. It also produces unparalleled reduction in cytokine production and superior phase-2 detoxification. Its action is aided by the addition of NAC, which can readily pass the blood brain barrier, performing similar function in neural tissue.

This unique combination increases serum glutathione and SOD, reduces TNF-a, IL6 and ROS, and regulates liver enzymes for effective control of inflammation and support of detoxification. Through the glutathione, it activates all autophagy genes, priming cells for the autophagy process. As an added benefit, it enhances collagen synthesis.

GI Soothe

GI Soothe is a formula designed to support gastrointestinal health and maximize nutritional absorption by decreasing GI inflammation and promoting repair of the gut lining.

It is free of laxatives, anti-microbials and allergens.  It can be used short term to help heal the gut, or long term to prevent intestinal irritation.

Menopause Management

The drop in estrogen at menopause causes a rise in Kisspeptin, Neurokinin B and cortisol, which stimulate warm-sensing neurons in the preoptic area, generating hot flashes. Stimulation of these neurons also increases the activity of GnRH and LH, enhancing the hot flash symptoms. Menopause Management is a unique combination of White Peony, Rehmannia, DIM and Lactium.

Together these ingredients lower levels of Kisspeptin, Neurokinin-B and cortisol, while increasing the conversion of 4-OH estrogen into 2-OH. This allows safe treatment of hot flashes and other menopausal symptoms, without the disease risk associated with hyperstimulation of breast, ovarian and endometrial tissue. This formula can also be safely used with cancer patients.

Neural Repair

A combination of Resveratrol, Astaxanthin and Superoxide Dismutase that supports neural function and autophagy, while moderating systemic inflammation throughout the body.

This powerful formula can safely be combined with any neurological or anti-inflammatory medication.

Quercetin and Bromelain

Quercetin-bromelain is a bioflavonoid complex with antioxidant and mast cell stabilizing properties.

Quercetin has a poor 30% absorption rate when taken on its own. When combined with Bromelain, plasma levels of quercetin are up to 20 times higher, exerting a powerful therapeutic effect.

Quercetin and bromelain help support the immune system.

Rest Reset

Rest Reset is a unique formula that resets the HPA axis and autonomic nervous system to the parasympathetic side, increases the production and binding of GABA to aid sleep, and Melatonin to allow for easy transition into delta wave deep sleep.

Please note that this supplement should not be used as a sleep aid in the middle of the night.

Rest Reset (High Potency)

A higher-dosed Melatonin formula combined with Passion Flower and Lactium Casein Hydrolysate (Lactium). High Potency Rest Reset contains 10 mg of melatonin (compared to 3 mg in regular Rest Reset). New research indicates that the previous dosing of melatonin was far too low and higher dosing is needed to support delta-wave deep sleep, increase serotonin production, reduce inflammation, block 4-OH-estrogen receptors and support a variety of anti-cancer pathways.

This formula can safely be combined with any sleep aid but should not be taken in the middle of the night as an aid to falling back asleep.

Sleep Return

A combination of Valerian, Chamomile, Lemon Balm and Passion Flower. Sleep Return does not contain melatonin, making it ideal to take just before bed and, if needed, in the middle of the night to help you quickly return to sleep without morning grogginess. This in turn helps to reduce the stress and anxiety associated with nighttime waking, once again allowing for a better deeper sleep.

Combined, these key ingredients gently calm and relax the body, inducing a deeper, more relaxing sleep.

Stress Reset

A unique combination of Lactium Casein Hydrolysate (containing bioactive peptides) and SunTheanine. Stress Reset acts to balance the nervous system and restore parasympathetic drive, rather than simply dampening the sympathetic side.

FK-binding-protein-5 binds to mineralocorticoid receptors and prevents the HPA-axis from turning off, even in the absence of a stressor.

Together this unique formula plays a crucial role in the treatment of stress and stress-induced conditions. It helps manage the treatment of over 90% of genes which are blocked by HPA over-stimulation.

This product can be used safely in combination with any mood stabilizer or sleeping pill.

Testo-Protect

Testo-Protect is a formula designed for both men and women to help decrease excess testosterone levels.

It decreases the conversion of testosterone into the more active and harmful dihydrotestosterone (DHT).

Thyroid Reset

A formula combining Blue Flag, Coleus Forskohlii, Guggul Lipids, Selenium and Iodine, to activate adenylate cyclase and directly increase the production of T3, thereby strengthening thyroid activity. Lactium and Ashwagandha are added to prevent the conversion of T4 and T3 into Reverse T3, and to help regulate both the HPA and HPT (hypothalamus-pituitary-thyroid) axes.

These ingredients prevent excessive HPA stimulation from deregulating the HPT axis, the most common cause of thyroid dysfunction. This product will boost thyroid activity safely and can be combined with pharmaceutical thyroid medications.

TMC

A combination of L-Carnosine, Berberine HCl and Resveratrol that aids in weight loss and diabetes management. It also increases a patient’s ability to adhere to a healthy diet, important for long term weight control.

Together these ingredients regulate the main hormones that control our metabolic rate. They prevent leptin resistance, reduce ghrelin, and increase the production of GLP-1, adiponectin, PGC1-a and SIRT6 to effectively control hunger, satiety, food cravings and the rate of adipogenesis and lipolysis. This product can be used in conjunction with pharmaceutical GLP1 agonists helping to prevent GLP-1 agonist dependency.